Puppy Linux allows you to run a persistent instance (not a Live CD) of Linux directly from a USB flash drive

If you’re looking to run Linux from a USB flash drive, Puppy Linux is the best option. Why? It can function from removable storage devices. It comes with every program you will ever need. And, best of all, Puppy comes in dozens of Linux flavors, like Ubuntu, which many people are already familiar with.

Puppy Linux is a persistent Linux operating system. Persistent means that once Puppy is flashed to your USB device, the USB will act like a computer hard drive. So, no matter how many pictures, videos, or music files you put on it or how many websites you visit, everything will stay the same each time you boot into Puppy.

Puppy Linux is only around 300 MB in size.

See how to set it up at How to run Linux from a USB flash drive

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If you're looking to run Linux from a USB flash drive, Puppy Linux is the best option. Why? It can function from removable storage devices. It comes with %

source https://gadgeteer.co.za/puppy-linux-allows-you-run-persistent-instance-not-live-cd-linux-directly-usb-flash-drive